In 1854, London physician Dr. John Snow mapped the spatial relationship between deaths from the waterborne disease cholera and the locations of water pumps which brought in water directly from tunnels connected to the River Thames. From Snow's research it was determined that a public water pump had been contaminated by sewage.What geographic principle explains the significance of Snow's research?A) As cities remove natural resources from the landscape, those resources become insignificant.B) Even in areas of urban land use, there is a significant relationship between nature and society.C) Once water enters an area of urban land use, that water is no longer considered a natural resource.D) The prosperity of a society is determined by environmental factors, such as the availability of natural resources.E) Societies leave a cultural imprint on the land, such as the pattern of streets and water systems.

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