Why was Cahokia significant? Cahokia was the center of Mayan culture. Cahokia was a large metropolis on the Mississippi River that built its economy on river-borne trade. Cahokia was the largest city in the Maya empire and contains pyramids similar to those found in Egypt. Cahokia was a mythical city where many Indians believed life in North America began. Cahokia was a large city located in present-day Mexico that served as the main trading center for the entire area.

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